Photoalteration of calcium channel blockade in the cardiac Purkinje fiber.

@article{Sanguinetti1984PhotoalterationOC,
  title={Photoalteration of calcium channel blockade in the cardiac Purkinje fiber.},
  author={Michael C Sanguinetti and R. S. Kass},
  journal={Biophysical journal},
  year={1984},
  volume={45 5},
  pages={873-80}
}
Organic compounds that block calcium channel current (calcium antagonists) are important tools for the characterization of this channel. However, the practically irreversible nature of this block restricts the usefulness of this group of drugs. In this paper, we investigate the influence of light on calcium channel blockade by several organic compounds. Our results show that inhibition of calcium channel current by two dihydropyridine derivatives that contain an o-nitro moiety (nisoldipine and… CONTINUE READING

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