Photoaffinity-labeling peptide substrates for farnesyl-protein transferase and the intersubunit location of the active site.

Abstract

--CAAX motif peptides, which are substrates for isoprenylation, were synthetically derivatized with the light-sensitive benzophenone (Bz) group in order to determine their potential use as catalytic site-directed covalent photocross-linking ligands for one of the enzymes catalyzing protein isoprenylation, farnesyl-protein transferase (FPTase). Bz-peptides… (More)

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