Photoaffinity labeling of the purified skeletal muscle calcium antagonist receptor by a novel benzothiazepine, [3H]azidobutyryl diltiazem.

@article{Naito1989PhotoaffinityLO,
  title={Photoaffinity labeling of the purified skeletal muscle calcium antagonist receptor by a novel benzothiazepine, [3H]azidobutyryl diltiazem.},
  author={Kazuaki Naito and Edward McKenna and Arnold Schwartz and P. L. Vaghy},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 35},
  pages={21211-4}
}
Previous photoaffinity-labeling studies with [3H]azidopine, (+) [3H]PN200-110, and [3H]LU 49888 have demonstrated that 1,4-dihydropyridines (nifedipine-like drugs) and phenylalkylamines (verapamil-like drugs) bind exclusively to the 165-kDa alpha 1 subunit of skeletal muscle calcium channels. However, it has not been conclusively determined whether… CONTINUE READING