Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily.

@article{Pellequer1998PhotoactiveYP,
  title={Photoactive yellow protein: a structural prototype for the three-dimensional fold of the PAS domain superfamily.},
  author={J-L. Pellequer and Karen Wager-Smith and Steve A Kay and Elizabeth D. Getzoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 11},
  pages={5884-90}
}
PAS domains are found in diverse proteins throughout all three kingdoms of life, where they apparently function in sensing and signal transduction. Although a wealth of useful sequence and functional information has become recently available, these data have not been integrated into a three-dimensional (3D) framework. The very early evolutionary development and diverse functions of PAS domains have made sequence analysis and modeling of this protein superfamily challenging. Limited sequence… CONTINUE READING