Photoactivation of an Acid-Sensitive Ion Channel Associated with Vision and Pain.

Abstract

We describe the reversible photoactivation of the acid sensitive ligand-gated ion channel ASIC2a, a mammalian channel found throughout the central and peripheral nervous systems that is associated with vision and pain. We also show the activation of GLIC, an acid-sensitive prokaryotic homologue of the nicotinic acetylcholine receptor. Photoactivation was… (More)
DOI: 10.1002/cbic.201600230

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