Photoactivatable Neuropeptides for Spatiotemporally Precise Delivery of Opioids in Neural Tissue

@article{Banghart2012PhotoactivatableNF,
  title={Photoactivatable Neuropeptides for Spatiotemporally Precise Delivery of Opioids in Neural Tissue},
  author={Matthew R Banghart and Bernardo L. Sabatini},
  journal={Neuron},
  year={2012},
  volume={73},
  pages={249-259}
}
Neuropeptides activate G protein-coupled receptors to acutely modulate cellular excitability and synaptic transmission. However, due to the lack of reagents for precise delivery of peptides within dense brain tissue, the spatiotemporal scale over which neuropeptides act is unknown. To achieve rapid and spatially delimited delivery of neuropeptides in mammalian brain tissue, we developed photoactivatable analogs of two opioids: [Leu⁵]-enkephalin (LE) and the 8 amino acid form of Dynorphin A (Dyn… CONTINUE READING
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