Photoacoustic flow cytometry: principle and application for real-time detection of circulating single nanoparticles, pathogens, and contrast dyes in vivo.

@article{Zharov2007PhotoacousticFC,
  title={Photoacoustic flow cytometry: principle and application for real-time detection of circulating single nanoparticles, pathogens, and contrast dyes in vivo.},
  author={Vladimir P Zharov and Ekaterina I Galanzha and Evgeny V. Shashkov and Jin-Woo Kim and Nikolai G Khlebtsov and Valery V. Tuchin},
  journal={Journal of biomedical optics},
  year={2007},
  volume={12 5},
  pages={
          051503
        }
}
The goal of this work is to develop in vivo photoacoustic (PA) flow cytometry (PAFC) for time-resolved detection of circulating absorbing objects, either without labeling or with nanoparticles as PA labels. This study represents the first attempt, to our knowledge, to demonstrate the capability of PAFC with tunable near-infrared (NIR) pulse lasers for real-time monitoring of gold nanorods, Staphylococcus aureus and Escherichia coli labeled with carbon nanotubes (CNTs), and contrast dye… CONTINUE READING

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