Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters

Abstract

The visible-light-driven, phase-transfer-catalyzed, enantioselective perfluoroalkylation and trifluoromethylation of cyclic β-ketoesters is described. The photo-organocatalytic process, which occurs at ambient temperature and under visible light illumination, is triggered by the photochemical activity of in situ-generated electron donor-acceptor complexes, arising from the association of chiral enolates and perfluoroalkyl iodides. Preliminary mechanistic studies are reported.

DOI: 10.1021/jacs.5b03243

Cite this paper

@inproceedings{Woniak2015PhotoorganocatalyticEP, title={Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters}, author={Łukasz Woźniak and John Murphy and Paolo Melchiorre}, booktitle={Journal of the American Chemical Society}, year={2015} }