Photo-induced reactions of benzo(a)pyrene with DNA in vitro.

  title={Photo-induced reactions of benzo(a)pyrene with DNA in vitro.},
  author={G F Strniste and Eduardo F. Martinez and A. Marina Martinez and R. J. Brake},
  journal={Cancer research},
  volume={40 2},
The induction of lesions in DNA by combinations of benzo(a)pyrene (B(a)P) and near-ultraviolet light (NUV) with wavelengths of 300 to 480 nm was investigated. Using centrif ugal methods or agarose gel electrophoretic techniques to monitor the conversion of the superhelical double-stranded PM2 DNA to the relaxed circular form, it was possible to quantitate the rates of single-strand breakage in the DNA when analyzed in neutral or alkaline conditions. Irradiation of a B(a)P and DNA mixture with… CONTINUE READING

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