Photo-induced graft-versus-host disease.


Overlap chronic graft-versus-host disease (GVHD) associates both features of acute and chronic GVHD. Trigger factors for chronic GVHD are unclear. We describe two patients who received allogenic haematopoietic stem-cell transplantation, and who later developed overlap chronic GVHD after sun exposure. Available data from in vivo investigations suggest ultraviolet B radiation (UVB) has a beneficial effect on acute and chronic GVHD. The role of sun irradiation as a trigger for isomorphic cutaneous GVHD has been rarely reported in the literature. Herein, we demonstrate for the first time, using repetitive broadband phototesting, that UVB triggers chronic GVHD.

DOI: 10.1111/phpp.12273

Cite this paper

@article{Hardy2016PhotoinducedGD, title={Photo-induced graft-versus-host disease.}, author={Juliette M Hardy and Marie-Claude Marguery and Anne Huynh and C{\'e}cile Borel and Pol Andr{\'e} Apoil and Laurence Lamant and Emilie Tournier and Chlo{\'e} Alberto and C{\'e}line Pauwels and Marianne Thomas and Juliette Mazereeuw Hautier and C Paul and C Bulai Livideanu}, journal={Photodermatology, photoimmunology & photomedicine}, year={2016}, volume={32 5-6}, pages={291-295} }