Photo-Ablation of Human Vitreous Opacities by Light-Induced Vapor Nanobubbles.

@article{Sauvage2019PhotoAblationOH,
  title={Photo-Ablation of Human Vitreous Opacities by Light-Induced Vapor Nanobubbles.},
  author={F{\'e}lix Sauvage and Juan C. Fraire and Katrien Remaut and J. Sebag and Karen Peynshaert and Michael G. Harrington and F Van de velde and Ranhua Xiong and Marie Jos{\'e} Tassignon and Toon Brans and Kevin Braeckmans and Stefaan C. De Smedt},
  journal={ACS nano},
  year={2019}
}
Myopia, diabetes and aging are the main causes of progressive vitreous collagen aggregation, resulting in vitreous opacities which can significantly disturb vision. As vitreous opacities, which induce the visual phenomenon of 'floaters', are accessible with nanomaterials and light, we propose a nanotechnology-based approach to locally ablate them with highly reduced light energy compared to the more traditional YAG laser therapy. Our strategy relies on the plasmon properties of gold… 

Laser-induced nanobubbles safely ablate vitreous opacities in vivo

‘nanobubble ablation’ for safe destruction of vitreous opacities is introduced and exposed gold nanoparticles or indocyanine green to low-energy laser pulses generates vapour nanobubbles that can disrupt collagen aggregates in the eyes of rabbit, suggesting a milder strategy for the treatment of eye floaters.

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters.

It is demonstrated that fibrillation of collagen I is prevented most strongly by positively charged CQDs (CQDs-2) and that pulsed-laser illumination allowed to destroy type I collagen aggregates and vitreous opacities (as obtained from patients after vitrectomy) treated with CQD-2.

ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery.

Vitreous and Vision Degrading Myodesopsia

  • J. Sebag
  • Medicine
    Progress in Retinal and Eye Research
  • 2020

Photodisruption of the Inner Limiting Membrane: Exploring ICG Loaded Nanoparticles as Photosensitizers

Application of ICG liposomes followed by laser treatment resulted in subtle disruption effects at the ILM where zones of fully ablated ILM were alternated by intact regions, improving the concept to a further extent.

Bubble Forming Films for Spatial Selective Cell Killing

It is foreseen that bubble-films might become promising for safe resection of superficial tumors because of their ability to kill cells in close proximity to the films due to mechanical forces which arise when the bubbles collapse.

Ocular Nanomedicine

In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state‐of‐the‐art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized.

Spontaneous posterior vitreous detachment: A glance at the current literature

The take home message is that an ophthalmic examination at the onset of symptoms is of utmost importance, considering that irreversible sight-threatening complications can be prevented if diagnosed and treated promptly.

References

SHOWING 1-10 OF 69 REFERENCES

Vitreous: a barrier to nonviral ocular gene therapy.

Whether vitreous is a barrier for the LPXs and to find strategies to overcome this barrier, and how to modify the surfaces ofLPXs with hydrophilic PEG chains prevents them from aggregating in vitreOUS.

Cataracts induced by neodymium–yttrium-aluminium-garnet laser lysis of vitreous floaters

Two patients who underwent ND:YAG laser vitreolysis for symptomatic floaters, presented with decline in visual acuity in the treated eye after the laser procedure, indicating secondary cataract formation accompanied by loss of integrity of the posterior capsule is a potential complication of Nd: yttrium-aluminium-garnet laser vitREolysis.

Vitreous Humor Rheology After Nd:YAG Laser Photo Disruption

The results showed that, the anterior vitreous group exposed to of 5 mJ × 100 pulse and/or supplemented with vitamin C, showed no obvious change, and all other treated groups especially for mid-vitreous and posterior Vitreous humor showed increase in the protein content, RI and the viscosity of vitreOUS humor.

Eligibility criteria for Nd-YAG laser treatment of highly symptomatic vitreous floaters.

Ten eyes of nine patients were treated for very disturbing vitreous floaters with the technique of Nd-YAG laser vitreolysis, with the well- Suspended floaters responding better to treatment compared to the ill-suspended vitreOUS floaters.

Age-related changes in human vitreous structure

  • J. Sebag
  • Medicine
    Graefe's Archive for Clinical and Experimental Ophthalmology
  • 2005
Characterization of the molecular events underlying changes will elucidate the mechanisms of the phenomena of synchisis, syneresis, and detachment, and may provide methods with which to prevent or induce vitreous detachment prophylactically.

Treatment of vitreous floaters with neodymium YAG laser.

The initial experience indicates that the use of neodymium YAG laser to treat vitreous floaters with serious psychological reactions is simple, safe, and effective.

Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo.

Coating nanocarriers with hyaluronic acid facilitates intravitreal drug delivery for retinal gene therapy.

...