Photic regulation of melatonin in humans: ocular and neural signal transduction.

  title={Photic regulation of melatonin in humans: ocular and neural signal transduction.},
  author={George C. Brainard and Mark D. Rollag and John P. Hanifin},
  journal={Journal of biological rhythms},
  volume={12 6},
Light is a potent stimulus for regulating the pineal gland's production of melatonin and the broader circadian system in humans. It initially was thought that only very bright photic stimuli (> or = 2500 lux) could suppress nocturnal melatonin secretion and induce other circadian responses. It is now known that markedly lower illuminances (< or = 200 lux) can acutely suppress melatonin or entrain and phase shift melatonin rhythms when exposure conditions are optimized. The elements for physical… CONTINUE READING

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