Photic inhibition of TrkB/Ras activity in the pigeon's tectum during development: impact on brain asymmetry formation.

@article{Manns2005PhoticIO,
  title={Photic inhibition of TrkB/Ras activity in the pigeon's tectum during development: impact on brain asymmetry formation.},
  author={Martina Manns and Onur G{\"u}nt{\"u}rk{\"u}n and Rolf Heumann and Andrea Bl{\"o}chl},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 9},
  pages={2180-6}
}
Asymmetric photic stimulation during embryonic or post-hatch development induces a functional lateralization of the pigeon's visual system, which is accompanied by left-right differences in tectal cell sizes. The intracellular membrane-anchored GTPase Ras can be activated by a number of upstream mechanisms including binding of brain-derived neurotrophic factor to its specific TrkB receptor. Ras activity plays an important morphogenetic role in neurons and therefore might also be involved in the… CONTINUE READING
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