Photic and circadian regulation of retinal melatonin in mammals.

  title={Photic and circadian regulation of retinal melatonin in mammals.},
  author={Gianluca Tosini and Chiaki Fukuhara},
  journal={Journal of neuroendocrinology},
  volume={15 4},
Several studies have established that melatonin synthesis occurs in the retina of vertebrates, including mammals. In mammals, a subpopulation of photoreceptors (probably the cones) synthesize melatonin. Melatonin synthesis in the retina is elevated at night and reduced during the day in a fashion similar to events in the pineal gland. Both the MT1 and MT2 melatonin receptors are present in the retina and retinal melatonin does not contribute to circulating levels, suggesting that retinal… CONTINUE READING
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