Photic Regulation of Map Kinase Phosphatases MKP1/2 and MKP3 in the Hamster Suprachiasmatic Nuclei

@article{Pizzio2007PhoticRO,
  title={Photic Regulation of Map Kinase Phosphatases MKP1/2 and MKP3 in the Hamster Suprachiasmatic Nuclei},
  author={Gaston A Pizzio and Diego Andr{\'e}s Golombek},
  journal={Journal of Molecular Neuroscience},
  year={2007},
  volume={34},
  pages={187-192}
}
MAP kinases (MAPKs) play a key role in photic entrainment signaling in the suprachiasmatic nuclei (SCN), the mammalian circadian clock. The control of MAPKs is a fine balance between specific kinases (MEKs) and phosphatases (MKPs), whose orchestration in the SCN is still unresolved. We have found MKP1/2 and MKP3 immunoreactive-cells in the hamster SCN, whose levels are rapidly increased in response to transient light stimulation in the subjective night (CT 18), when light is able to entrain the… CONTINUE READING
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