Phosphotyrosines in the Killer Cell Inhibitory Receptor Motif of NKB 1 Are Required for Negative Signaling

@inproceedings{Fry2003PhosphotyrosinesIT,
  title={Phosphotyrosines in the Killer Cell Inhibitory Receptor Motif of NKB 1 Are Required for Negative Signaling},
  author={Mark Fry and Lewis L. Lani and Arthur Weiss},
  year={2003}
}
NKB1 is one member o f a ~owing family ofkiUer cell inhibitory receptms (K/R~. It is expressed on natural kilIer (NK) cells and T cells, and has been showrt to inhibit cytolytic s tions of these cells upon interacting ~ t h its hga~,, HLA-B (Bw4). We demongrate he_xe that the cytoplasmic' region of NKB1 is capab~ of inhibiting T cell, activation m jmrkat cdls. ~ e ty~osme phosphorylation of the NKBI KtR consensus motif, YxxL(x)~YxxL, induces an amoc/afion with the protein tyrosine phosphat~.se… CONTINUE READING