Phosphotyrosine phosphatase and tyrosine kinase inhibition modulate airway pressure-induced lung injury.

  title={Phosphotyrosine phosphatase and tyrosine kinase inhibition modulate airway pressure-induced lung injury.},
  author={James Courtney Parker and Claire L Ivey and Alan Tucker},
  journal={Journal of applied physiology},
  volume={85 5},
We determined whether drugs which modulate the state of protein tyrosine phosphorylation could alter the threshold for high airway pressure-induced microvascular injury in isolated perfused rat lungs. Lungs were ventilated for successive 30-min periods with peak inflation pressures (PIP) of 7, 20, 30, and 35 cmH2O followed by measurement of the capillary filtration coefficient (Kfc), a sensitive index of hydraulic conductance. In untreated control lungs, Kfc increased by 1.3- and 3.3-fold… CONTINUE READING


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