Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C.

  title={Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C.},
  author={Melody A. Campbell and Norman R. Klinman},
  journal={European journal of immunology},
  volume={25 6},
CD22 is a B lymphocyte-specific cell surface glycoprotein that becomes tyrosine phosphorylated upon B cell activation. To determine if tyrosine phosphorylated CD22 couples signaling through membrane immunoglobulin (mIg) to down-stream elements, we looked for molecules coprecipitating with CD22 after anti-Ig stimulation. We found that a 60-kDa molecule was stably associated with CD22 following cross-linking of mIg and have identified this molecule as protein tyrosine phosphatase 1C (PTP1C). The… CONTINUE READING
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