Phosphotransfer profiling: systematic mapping of two-component signal transduction pathways and phosphorelays.

@article{Laub2007PhosphotransferPS,
  title={Phosphotransfer profiling: systematic mapping of two-component signal transduction pathways and phosphorelays.},
  author={Michael T Laub and Emanuele G. Biondi and Jeffrey M Skerker},
  journal={Methods in enzymology},
  year={2007},
  volume={423},
  pages={531-48}
}
Two-component signal transduction systems, composed of histidine kinases and response regulators, enable bacteria to sense, respond, and adapt to changes in their internal and external conditions. The importance of these signaling systems is reflected in their widespread distribution and prevalence in the bacterial kingdom, with some organisms encoding as many as 250 two-component signaling proteins. In many cases, a histidine kinase and a response regulator are encoded in the same operon and… CONTINUE READING

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