Phosphotidylethanol mimics ethanol modulation of p42/44 mitogen-activated protein kinase signalling in hepatocytes.

@article{Aroor2002PhosphotidylethanolME,
  title={Phosphotidylethanol mimics ethanol modulation of p42/44 mitogen-activated protein kinase signalling in hepatocytes.},
  author={Annayya R. Aroor and Geoffrey W Custer and Yu-I Weng and Youn Ju Lee and Shivendra D. Shukla},
  journal={Alcohol and alcoholism},
  year={2002},
  volume={37 6},
  pages={534-9}
}
AIMS Although long-term exposure of hepatocytes to ethanol results in agonist-selective potentiation of p42/44 mitogen-activated protein kinase (MAPK) activation, mediators of this effect of ethanol are not known. METHODS We examined the role of phosphatidylethanol (PEth), a novel phospholipid formed exclusively in the presence of ethanol. RESULTS PEth accumulated in primary cultures of rat hepatocytes treated with ethanol. Exogenously added PEth potentiated angiotensin II-stimulated p42/44… CONTINUE READING
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