Phosphorylcholine on isologous red blood cells induces polyclonal but not anti‐phosphorylcholine plaque‐forming cells in mice

@article{Beckmann1984PhosphorylcholineOI,
  title={Phosphorylcholine on isologous red blood cells induces polyclonal but not anti‐phosphorylcholine plaque‐forming cells in mice},
  author={Enrique Beckmann and M. A. Bach and Daniel Levitt},
  journal={European Journal of Immunology},
  year={1984},
  volume={14}
}
It has been demonstrated in the preceeding report (Bach, M. A., Beckmann, E. and Levitt, D., Eur. J. Immunol. 1984. 14: 589) that phosphorylcholine (PC) on the bacterium Streptococcus pneumoniae R36a stimulated polyclonal as well as anti‐PC plaque‐forming cells (PFC) in mouse spleen in vivo. In this study, red blood cells from BALB/c mice (MRBC) were either conjugated with PC, 2,4,6‐trinitrophenyl (TNP) or treated with phospholipase A2 (PLA2) to expose PC on the cell membrane (determined by… 
Pneumococcal cell wall phosphorylcholine elicits polyclonal antibody secretion in mice
TLDR
From the results, it appears that PC on the cell wall of a bacterium acts both as a polyclonal activator and a specific antigen, stimulating each by different mechanisms.
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From the results, it appears that PC on the cell wall of a bacterium acts both as a polyclonal activator and a specific antigen, stimulating each by different mechanisms.
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