Phosphorylation state-specific antibodies: applications in investigative and diagnostic pathology.

@article{Mandell2003PhosphorylationSA,
  title={Phosphorylation state-specific antibodies: applications in investigative and diagnostic pathology.},
  author={James W Mandell},
  journal={The American journal of pathology},
  year={2003},
  volume={163 5},
  pages={1687-98}
}
Until recently, the investigation of protein phosphorylation was limited to biochemical studies of enzyme activities in homogenized tissues. The availability of hundreds of phosphorylation state-specific antibodies (PSSAs) now makes possible the study of protein phosphorylation in situ, and is opening many exciting opportunities in investigative and diagnostic pathology. This review illustrates the power of PSSAs, especially in immunohistochemical applications to human disease and animal models… CONTINUE READING

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