Phosphorylation sites of Epstein-Barr virus EBNA1 regulate its function.

  title={Phosphorylation sites of Epstein-Barr virus EBNA1 regulate its function.},
  author={Sarah J. Duellman and Katie L Thompson and Joshua J. Coon and R. R. Burgess},
  journal={The Journal of general virology},
  volume={90 Pt 9},
Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis and a risk factor for developing a variety of lymphomas and carcinomas. EBV nuclear antigen 1 (EBNA1) is the only viral protein found in all EBV-related malignancies. It plays a key role in establishing and maintaining the altered state of cells transformed with EBV. EBNA1 is required for a variety of functions, including gene regulation, replication and maintenance of the viral genome, but the regulation of EBNA1's… CONTINUE READING