Phosphorylation site localization in peptides by MALDI MS/MS and the Mascot Delta Score.

@article{Lemeer2012PhosphorylationSL,
  title={Phosphorylation site localization in peptides by MALDI MS/MS and the Mascot Delta Score.},
  author={Simone Lemeer and Elena Kunold and Susan Klaeger and Monika Raabe and Mark W. Towers and Emmanuelle Claudes and Tabiwang N. Arrey and Kerstin Strupat and Henning Urlaub and Bernhard Kuster},
  journal={Analytical and bioanalytical chemistry},
  year={2012},
  volume={402 1},
  pages={249-60}
}
Owing to its broad biological significance, the large-scale analysis of protein phosphorylation is more and more getting into the focus of proteomic research. Thousands of phosphopeptides can nowadays be identified using state-of-the-art tandem mass spectrometers in conjunction with sequence database searching, but localizing the phosphate group to a particular amino acid in the peptide sequence is often still difficult. Using 180 individually synthesized phosphopeptides with precisely known… CONTINUE READING

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