Phosphorylation regulates kinase and microtubule binding activities of the budding yeast chromosomal passenger complex in vitro.

@article{Cormier2013PhosphorylationRK,
  title={Phosphorylation regulates kinase and microtubule binding activities of the budding yeast chromosomal passenger complex in vitro.},
  author={Anthony Cormier and David G Drubin and Georjana Barnes},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 32},
  pages={23203-11}
}
The chromosomal passenger complex (CPC) is a key regulator of mitosis in eukaryotes. It comprises four essential and conserved proteins known in mammals/yeasts as Aurora B/Ipl1, INCENP/Sli15, Survivin/Bir1, and Borealin/Nbl1. These subunits act together in a highly controlled fashion. Regulation of Aurora B/Ipl1 kinase activity and localization is critical for CPC function. Although regulation of CPC localization and kinase activity in vivo has been investigated elsewhere, studies on the… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…