Phosphorylation regulates integration of the yeast Ty5 retrotransposon into heterochromatin.

  title={Phosphorylation regulates integration of the yeast Ty5 retrotransposon into heterochromatin.},
  author={Junbiao Dai and Weiwu Xie and Troy L. Brady and Jiquan Gao and Daniel F. Voytas},
  journal={Molecular cell},
  volume={27 2},
The yeast Ty5 retrotransposon preferentially integrates into heterochromatin at the telomeres and silent mating loci. Target specificity is mediated by a small domain of Ty5 integrase (the targeting domain, TD), which interacts with the heterochromatin protein Sir4 and tethers the integration complex to target sites. Here we demonstrate that TD is phosphorylated and that phosphorylation is required for interaction with Sir4. The yeast cell, therefore, through posttranslational modification… CONTINUE READING
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