Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.

@article{Wang2011PhosphorylationRC,
  title={Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.},
  author={Xiaoyan Wang and Melissa A Cunningham and Xiaoli Zhang and Sara A. Tokarz and Bryan Laraway and Megan L. Troxell and Rosalie C. Sears},
  journal={Cancer research},
  year={2011},
  volume={71 3},
  pages={925-36}
}
Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine 62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios of T58 and S62 phosphorylation have been observed in human cancer. Here, we report the development of 3 unique c-myc knock-in mice that conditionally express either c-Myc… CONTINUE READING