Phosphorylation regulates FOXC2-mediated transcription in lymphatic endothelial cells.


One of the key mechanisms linking cell signaling and control of gene expression is reversible phosphorylation of transcription factors. FOXC2 is a forkhead transcription factor that is mutated in the human vascular disease lymphedema-distichiasis and plays an essential role in lymphatic vascular development. However, the mechanisms regulating FOXC2… (More)
DOI: 10.1128/MCB.01387-12


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