Phosphorylation region of the yeast plasma-membrane H+-ATPase. Role in protein folding and biogenesis.

@article{Dewitt1998PhosphorylationRO,
  title={Phosphorylation region of the yeast plasma-membrane H+-ATPase. Role in protein folding and biogenesis.},
  author={N D Dewitt and Carlos Henrique Ferreira dos Santos and Kenneth E. Allen and Carolyn W. Slayman},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 34},
  pages={21744-51}
}
Mutations at the phosphorylation site (Asp-378) of the yeast plasma-membrane H+-ATPase have been shown previously to cause misfolding of the ATPase, preventing normal movement along the secretory pathway; Asp-378 mutations also block the biogenesis of co-expressed wild-type ATPase and lead to a dominant lethal phenotype. To ask whether these defects are specific for Asp-378 or whether the phosphorylation region as a whole is involved, alanine-scanning mutagenesis has been carried out to examine… CONTINUE READING

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