Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury.

@article{Koehler2011PhosphorylationOV,
  title={Phosphorylation of vasodilator-stimulated phosphoprotein prevents platelet-neutrophil complex formation and dampens myocardial ischemia-reperfusion injury.},
  author={David A. Koehler and Andreas Straub and Thomas Weissmueller and Marion Faigle and Sarah M Bender and Rainer Lehmann and Hans P. Wendel and Julia Kurz and Ulrich Walter and Kai Zacharowski and Peter Rosenberger},
  journal={Circulation},
  year={2011},
  volume={123 22},
  pages={2579-90}
}
BACKGROUND Recent work has suggested that the formation of platelet-neutrophil complexes (PNCs) aggravates the severity of inflammatory tissue injury. Given the importance of vasodilator-stimulated phosphoprotein (VASP) for platelet function, we pursued the role of VASP on the formation of PNCs and its impact on the extent of myocardial ischemia-reperfusion (IR) injury. METHODS AND RESULTS In initial in vitro studies we found that neutrophils facilitated the movement of platelets across… CONTINUE READING