Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart

@article{Kranias1982PhosphorylationOT,
  title={Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart},
  author={Evangelia G Kranias and R. John Solaro},
  journal={Nature},
  year={1982},
  volume={298},
  pages={182-184}
}
During adrenergic stimulation heart cells develop increased force and there is an increase in the rate of rise and fall of force. These changes are thought to be triggered by the binding of catecholamine to the β-receptor, which in turn signals alterations in membranes and the contracto-regulatory protein complex by multiple, coordinated mechanisms involving Ca2+, cyclic nucleotides and protein phosphorylation1,2. This view is supported by results of in vitro studies with cardiac myofibrils3,4… CONTINUE READING
75 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

Similar Papers

Loading similar papers…