Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

@article{Gille1992PhosphorylationOT,
  title={Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter},
  author={Hendrik Gille and Andrew D Sharrocks and Peter E. Shaw},
  journal={Nature},
  year={1992},
  volume={358},
  pages={414-417}
}
TRANSCRIPTION of the proto-oncogene c-fos is stimulated rapidly and transiently by serum growth factors and mitogens1. Critical for this response is the serum-response element which is bound in vivo in a ternary complex containing the transcription factors p67SRF and p62TCF (ref. 2). Disruption of the ternary complex correlates with impaired induction by serum and phorbol ester3,4. Mitogen-activated protein (MAP) kinase is a serine/ threonine kinase which is activated 1-5 minutes after… CONTINUE READING
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