Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.

@article{Hutti2009PhosphorylationOT,
  title={Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.},
  author={Jessica E. Hutti and R. R. Leitch Shen and Derek W Abbott and Alicia Y. Zhou and Kam M. Sprott and John M. Asara and William C. Hahn and Lewis C. Cantley},
  journal={Molecular cell},
  year={2009},
  volume={34 4},
  pages={461-72}
}
The noncanonical IKK family member IKKepsilon is essential for regulating antiviral signaling pathways and is a recently discovered breast cancer oncoprotein. Although several IKKepsilon targets have been described, direct IKKepsilon substrates necessary for regulating cell transformation have not been identified. Here, we performed a screen for putative IKKepsilon substrates using an unbiased proteomic and bioinformatic approach. Using a positional scanning peptide library assay, we determined… CONTINUE READING
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