Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.

@article{Habib1999PhosphorylationOT,
  title={Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.},
  author={Aida Habib and Garret A. FitzGerald and Jacques Maclouf},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 5},
  pages={
          2645-51
        }
}
A single gene encodes the human thromboxane receptor (TP), of which there are two identified splice variants, alpha and beta. Both isoforms are rapidly phosphorylated in response to thromboxane agonists when overexpressed in human embryonic kidney 293 cells; this phenomenon is only slightly altered by inhibitors of protein kinase C. Pharmacological studies have defined two classes of TP in human platelets; sites that bind the agonist I-BOP with high affinity support platelet shape change. Low… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 45 CITATIONS

The Gq and G12 families of heterotrimeric G proteins report functional selectivity.

  • Molecular pharmacology
  • 2009
VIEW 3 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED