Phosphorylation of the synaptic protein interaction site on N-type calcium channels inhibits interactions with SNARE proteins.

@article{Yokoyama1997PhosphorylationOT,
  title={Phosphorylation of the synaptic protein interaction site on N-type calcium channels inhibits interactions with SNARE proteins.},
  author={Charles T. Yokoyama and Zonggen Sheng and William A. Catterall},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 18},
  pages={6929-38}
}
The synaptic protein interaction (synprint) site on the N-type calcium channel alpha1B subunit binds to the soluble N-ethylmaleimide-sensitive attachment factor receptor (SNARE) proteins syntaxin and synaptosomal protein of 25 kDa (SNAP-25), and this association may be required for efficient fast synaptic transmission. Protein kinase C (PKC) and calcium and calmodulin-dependent protein kinase type II (CaM KII) phosphorylated a recombinant his-tagged synprint site polypeptide rapidly to a… CONTINUE READING
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