Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.

@article{Shan2010PhosphorylationOT,
  title={Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.},
  author={Jian Cheng Shan and Alexander Kushnir and Matthew J. Betzenhauser and Steven R. Reiken and Jingdong Li and Stephan E. Lehnart and Nicolas Lindegger and Marco Mongillo and Peter J. Mohler and Andrew Robert Marks},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 12},
  pages={4388-98}
}
During the classic "fight-or-flight" stress response, sympathetic nervous system activation leads to catecholamine release, which increases heart rate and contractility, resulting in enhanced cardiac output. Catecholamines bind to β-adrenergic receptors, causing cAMP generation and activation of PKA, which phosphorylates multiple targets in cardiac muscle, including the cardiac ryanodine receptor/calcium release channel (RyR2) required for muscle contraction. PKA phosphorylation of RyR2… CONTINUE READING