Phosphorylation of the pheromone-responsive Gβ protein of Saccharomyces cerevisiae does not affect its mating-specific signaling function

@article{Li1998PhosphorylationOT,
  title={Phosphorylation of the pheromone-responsive Gβ protein of Saccharomyces cerevisiae does not affect its mating-specific signaling function},
  author={Erguang Li and Mary J. Cismowski and David E. Stone},
  journal={Molecular and General Genetics MGG},
  year={1998},
  volume={258},
  pages={608-618}
}
The pheromone-responsive Gβ subunit of Saccharomyces cerevisiae (encoded by STE4) is rapidly phosphorylated at multiple sites when yeast cells are exposed to mating pheromone. It has been shown that a mutant form of Ste4 lacking residues 310–346, ste4Δ310–346, cannot be phosphorylated, and that its expression leads to defects in recovery from pheromone stimulation. Based on these observations, it was proposed that phosphorylation of Ste4 is associated with an adaptive response to mating… CONTINUE READING