Phosphorylation of the outer surface of platelets enhances the effects of collagen on aggregation, ATP release, calcium translocation and phosphoinositide hydrolysis.

Phosphorylation of the outer surface of human platelets increases their functional responsiveness to subthreshold amounts of collagen. Collagen-stimulated platelet aggregation, release of ATP and changes in cytoplasmic ionized calcium levels were all enhanced by pretreatment with ATP plus a kinase purified from human plasma. [3H]-myo-inositol-labeled human… CONTINUE READING