Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation

@article{Gross2005PhosphorylationOT,
  title={Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation},
  author={Isabelle Mercedes Gross and Beno{\^i}t Lhermitte and Claire Domon-Dell and Isabelle Duluc and {\'E}lisabeth Martin and Christian Gaiddon and Mich{\`e}le Kedinger and Juergen Dipl Ing Freund},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={7955-7963}
}
The Caudal-related homeodomain transcription factor Cdx2 plays a key role in intestinal cell fate determination. Reduction of Cdx2 expression is a feature of many human colon carcinomas and inactivation of one cdx2 allele facilitates the development of invasive adenocarcinoma in the murine colon. Here, we investigated the post-translational regulation of Cdx2. We showed that various forms of Cdx2 coexist in the intestine and colon cancer cell lines, some of them being phosphorylated forms. We… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 24 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

J

  • T Sakaguchi, X Gu, HM Golden, E Suh, DB Rhoads, HC. Reinecker
  • Biol. Chem., 277, 21361–21370.
  • 2002
Highly Influential
20 Excerpts

Biochem

  • A Rodolosse, I Chantret, +4 authors M. Rousset
  • J., 315 (Part 1), 301–306.
  • 1996
Highly Influential
7 Excerpts

Am

  • HC Ee, T Erler, PS Bhathal, GP Young, RJ. James
  • J. Pathol., 147, 586–592.
  • 1995
Highly Influential
2 Excerpts

J

  • J Boulanger, A Vezina, +6 authors N. Rivard
  • Biol. Chem., 280, 18095–18107.
  • 2005

J

  • CS Park, SI Kim, +4 authors WK. Song
  • Biol. Chem., 279, 19592–19599.
  • 2004

Nat

  • K Aoki, Y Tamai, S Horiike, M Oshima, MM. Taketo
  • Genet., 35, 323–330.
  • 2003

Biochem

  • H Mutoh, Y Hakamata, +6 authors K. Sugano
  • Biophys. Res. Commun., 294, 470–479.
  • 2002

Nat

  • C. Abate-Shen
  • Rev. Cancer, 2, 777–785.
  • 2002
3 Excerpts

J

  • C Cillo, M Cantile, A Faiella, E. Boncinelli
  • Cell Physiol., 188, 161–169.
  • 2001

J

  • M Houde, P Laprise, D Jean, M Blais, C Asselin, N. Rivard
  • Biol. Chem., 276, 21885–21894.
  • 2001

Similar Papers

Loading similar papers…