Phosphorylation of the catalyic alpha-subunit constitutes a triggering signal for Na+,K+-ATPase endocytosis.

@article{Chibalin1998PhosphorylationOT,
  title={Phosphorylation of the catalyic alpha-subunit constitutes a triggering signal for Na+,K+-ATPase endocytosis.},
  author={Alexander V Chibalin and Carlos Humberto Pedemonte and Adrian I. Katz and Eric Feraille and Per Olof Berggren and Alejandro Mario Bertorello},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 15},
  pages={8814-9}
}
Inhibition of Na+,K+-ATPase activity by dopamine is an important mechanism by which renal tubules modulate urine sodium excretion during a high salt diet. However, the molecular mechanisms of this regulation are not clearly understood. Inhibition of Na+,K+-ATPase activity in response to dopamine is associated with endocytosis of its alpha- and beta-subunits, an effect that is protein kinase C-dependent. In this study we used isolated proximal tubule cells and a cell line derived from opossum… CONTINUE READING
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