Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2

@inproceedings{Du2016PhosphorylationOT,
  title={Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2},
  author={Wei Du and Gabriella M.A. Forte and Duncan L Smith and Janni Petersen},
  booktitle={Open biology},
  year={2016}
}
Cell proliferation, metabolism, migration and survival are coordinated through the tight control of two target of rapamycin (TOR) kinase complexes: TORC1 and TORC2. Here, we show that a novel phosphorylation of fission yeast Gad8 (AGC kinase) on the evolutionarily conserved threonine 6 (Thr6) prevents the physical association between Gad8 and TORC2. Accordingly, this block to protein interactions by Gad8 Thr6 phosphorylation decreases TORC2-controlled activation of Gad8. Likewise… CONTINUE READING
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