Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.

@article{Jiang2003PhosphorylationOT,
  title={Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.},
  author={H Y Jiang and Sheree A. Wek and Barbara C. McGrath and Donalyn L. Scheuner and Randal J Kaufman and Douglas R Cavener and Ronald C Wek},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 16},
  pages={5651-63}
}
Nuclear factor kappaB (NF-kappaB) serves to coordinate the transcription of genes in response to diverse environmental stresses. In this report we show that phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2) is fundamental to the process by which many stress signals activate NF-kappaB. Phosphorylation of this translation factor is carried out by a family of protein kinases that each respond to distinct stress conditions. During impaired protein folding and assembly in… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
143 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 143 extracted citations

Similar Papers

Loading similar papers…