Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.

Abstract

Bloom's syndrome (BS) is a human genetic disorder associated with cancer predisposition. The BS gene product, BLM, is a member of the RecQ helicase family, which is required for the maintenance of genome stability in all organisms. In budding and fission yeasts, loss of RecQ helicase function confers sensitivity to inhibitors of DNA replication, such as… (More)

Topics

  • Presentations referencing similar topics