Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory

@article{Lee2003PhosphorylationOT,
  title={Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory},
  author={Hey-Kyoung Lee and Kogo Takamiya and Jung-Soo Han and Hengye Man and Chong-Hyun Kim and Gavin Rumbaugh and Sandy T Yu and Lin Ding and Chun Ju He and Ronald S. Petralia and Robert J. Wenthold and Michela Gallagher and Richard L. Huganir},
  journal={Cell},
  year={2003},
  volume={112},
  pages={631-643}
}
Plasticity of the nervous system is dependent on mechanisms that regulate the strength of synaptic transmission. Excitatory synapses in the brain undergo long-term potentiation (LTP) and long-term depression (LTD), cellular models of learning and memory. Protein phosphorylation is required for the induction of many forms of synaptic plasticity, including LTP and LTD. However, the critical kinase substrates that mediate plasticity have not been identified. We previously reported that… CONTINUE READING
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