Phosphorylation of tau by fyn: implications for Alzheimer's disease.

  title={Phosphorylation of tau by fyn: implications for Alzheimer's disease.},
  author={Gloria Lee and Ramasamy Thangavel and V. K. Sharma and Joel M. Litersky and Kiran Bhaskar and Sandy M. Fang and Lana H. Do and Athena Andreadis and Gary W van Hoesen and Hanna Księżak-Reding},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 9},
The abnormal phosphorylation of tau protein on serines and threonines is a hallmark characteristic of the neurofibrillary tangles of Alzheimer's disease (AD). The discovery that tau could be phosphorylated on tyrosine and evidence that Abeta signal transduction involved tyrosine phosphorylation led us to question whether tyrosine phosphorylation of tau occurred during the neurodegenerative process. In this study we determined that human tau tyr18 was phosphorylated by the src family tyrosine… CONTINUE READING
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