Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration.

@article{Li2007PhosphorylationOT,
  title={Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration.},
  author={Hong-lian Li and Haihong Wang and Shi-jie Liu and Yan-qiu Deng and Yong-Jie Zhang and Q. I. Tian and Xiao-Chuan Wang and Xiao-qian Chen and Ying Yang and Jiayu Zhang and Qun Wang and Huaxi Xu and F L Liao and Jian-Zhi Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 9},
  pages={3591-6}
}
Hyperphosphorylated tau is the major protein subunit of neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. It is not understood, however, why the neurofibrillary tangle-containing neurons seen in the AD brains do not die of apoptosis but rather degeneration even though they are constantly awash in a proapoptotic environment. Here, we show that cells overexpressing tau exhibit marked resistance to apoptosis induced by various apoptotic stimuli, which also causes… CONTINUE READING

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