Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis.

  title={Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis.},
  author={Conrad Wang and K Chua and Wolfgang Seghezzi and Emma Lees and Or P Gozani and Robin F Reed},
  journal={Genes & development},
  volume={12 10},
The U2 snRNP component SAP 155 contacts pre-mRNA on both sides of the branch site early in spliceosome assembly and is therefore positioned near or at the spliceosome catalytic center. We have isolated a cDNA encoding human SAP 155 and identified its highly related Saccharomyces cerevisiae homolog (50% identity). The carboxy-terminal two-thirds of SAP 155 shows the highest conservation and is remarkably similar to the regulatory subunit A of the phosphatase PP2A. Significantly, SAP 155 is… CONTINUE READING
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The structure and function of proteins involved in mammalian pre-mRNA splicing

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