Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret.

  title={Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret.},
  author={Stefanie S. Schalm and Bryan A. Ballif and Sean M. Buchanan and Greg R Phillips and Tom Maniatis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 31},
The clustered protocadherins (Pcdhs) are a large family of cadherin-like transmembrane proteins expressed in the nervous system. Stochastic expression of Pcdh genes and alternative splicing of their pre-mRNAs have the potential to generate enormous protein diversity at the cell surface of neurons. At present, the regulation and function of Pcdh proteins are largely unknown. Here, we show that Pcdhs form a heteromeric signaling complex(es), consisting of multiple Pcdh isoforms, receptor tyrosine… CONTINUE READING
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