Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.

  title={Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.},
  author={Jieya Shao and William J. Welch and Nicholas A Diprospero and Marc I Diamond},
  journal={Molecular and cellular biology},
  volume={28 17},
Y-27632, an inhibitor of the Rho-associated kinase ROCK, is a therapeutic lead for Huntington disease (HD). The downstream targets that mediate its inhibitory effects on huntingtin (Htt) aggregation and toxicity are unknown. We have identified profilin, a small actin-binding factor that also interacts with Htt, as being a direct target of the ROCK1 isoform. The overexpression of profilin reduces the aggregation of polyglutamine-expanded Htt and androgen receptor (AR) peptides. This requires… CONTINUE READING