Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.

Abstract

Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, vardenafil, or tadalafil) or phosphorylation by cyclic nucleotide-dependent protein kinase causes an apparent conformational change in PDE5, as indicated by a shift in migration on non-denaturing PAGE gels and an altered pattern of tryptic digestion. Combination of cGMP and a PDE5 inhibitor or… (More)

Cite this paper

@article{Bessay2007PhosphorylationOP, title={Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.}, author={Emmanuel P Bessay and Roya Zoraghi and M. Blount and Kennard A Grimes and Alfreda Beasley and Sharron H. Francis and Jackie D . Corbin}, journal={Frontiers in bioscience : a journal and virtual library}, year={2007}, volume={12}, pages={1899-910} }